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Joshua A. Baccile

Assistant Professor

Research

Research in the Baccile group will leverage the engineering potential of artificial proteins to create and apply soft materials with unique structural, functional, and diagnostic capacities. We will initially focus on three main areas: (1) Measuring protein conformational changes that occur in hydrogels as a result of bulk material deformation and cell traction forces; (2) Characterizing metabolic responses associated with material-guided cell fate; and (3) Engineering nanocomposite artificial protein hydrogels. Central to our research efforts will be a multidisciplinary approach, integrating expertise in protein engineering, bio-organic, cell biology, and analytical chemistry. I aim to foster a group culture where students and postdocs can enjoy collaborative research, intellectual freedom, financial support for both research and travel, and professional development for careers in academia, industry and less conventional choices.


Education

B.S. in Chemistry at SUNY Cortland (2011)
PhD in Chemical Biology at Cornell University (2017)
PostDoc California Institute of Technology (Caltech) in Prof. David Tirrell’s lab


Awards and Recognitions

1st Place – Flash Science Competition, Boyce Thompson Institute

Simon Bauer Scholarship Award, Cornell University

NIH Chemistry-Biology Interface Fellow, Cornell University

Merck Award for Excellence in Organic Chemistry, SUNY Cortland

CRC Press Chemistry Achievement Award, SUNY Cortland


Publications

  1. Baccile, J.A.; Le, H.H; Pfannenstiel, B.T.; Bok, J.W.; Gomez, C.; Brandenburger, E.; Hoffmeister, D.; Keller, N.P.; Schroeder, F.C.; Diketopiperazine Formation in Gliotoxin Biosynthesis Requires Dedicated Cyclization and Thiolation Domains. Angew. Chem. Int. Ed. 2019, 58, 1-6. [doi]
  2. O’Neill, E.M.; Mucyn, T.S.; Patteson, J.B.; Finkel, O.M.; Chung, E.H.; Baccile, J.A.; Massolo, E.; Schroeder, F.C.; Dangl, J.L.; Li, B.; A New Bacterial Small Molecule Suppresses Plant Immune Response. 2018, Proc. Natl. Acad. Sci. USA. 115, E9514-9522. [doi]
  3. Spraker, J.E.; Weimann, P.; Baccile, J.A.; Venkatesh, N.; Schumacher, J.; Schroeder, F.C.; Sanchez, L.M.; Keller, N.P.; Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi. 2018, mBio (3), e00820-18. [doi]
  4. Meyer, J.M.; Bose, N.; Artyukhin, A.B.; Rodelsperger, C.; Markov, G.V.; Yim, J.J.: Grimm, D.; Claassen, M.; Panda, O.; Baccile, J.A.; Jolic, D.; Schroeder, F.C.; Sommer, R.J.; Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis. 2018, Cell Chem. Biol. 25, 787-796. [doi]
  5. Lim, F.Y.; Won, T.H.; Baccile, J.A.; Wisecaver, J.; Rokas, A.; Schroeder, F.C.; Keller, N.P.; Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus. 2018, mBio (3), e00785-18. [doi]
  6. *Khalid, S.; *Baccile, J.A.; *Spraker, J.E.; Bok, J.W.; Velk, T.A.; Imran, M.; Schroeder, F.C.; Keller, N.P.; NRPS-derived isoquinolines and lipopeptides mediate antagonism between plant pathogenic fungi and bacteria. 2017, ACS Chem. Biol. 13, 171-179. [doi]
  7. Liberti, M.V.; Wardell, S.E.; Ziwei, D.; Baccile, J.A.; Liu, X.; Gao, X.; Baldi, R.; Madhukar, N.S.; Mehrmohamadi, M.; Shestov, A.A.; Elemento, O.; Schroeder, F.C.; McDonnell, D.P.; Locasale, J.W.; A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. 2017, Cell Metab. 26, 648-659. [doi]
  8. *Hind, S.R.; *Hoki, J.S.; Baccile, J.A.; Boycle, P.C.; Schroeder, F.C.; Martin, G.B.; Detecting the interaction of peptide ligands with plant membrane receptors. 2017, Curr. Protoc. Plant Biol. 2, 240-269. [doi]
  9. McClure, R.A.; Goering, A.W.; Ju, K.S.; Baccile, J.A.; Schroeder, F.C.; Metcalf, W.W.; Thomson, R.J.; Kelleher, N.L.; Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations. 2016, ACS Chem Biol. 11, 3452-3460. [doi]
  10. *Baccile, J.A.; *Spraker, J.E.; Le, H.H.; Brandenburger, E.; Gomez, C.; Bok, J.W.; Macheleidt, J.; Brakhage, A.A.; Hoffmeister, D.; Keller, N.P.; Schroeder, F.C.; Plant-like isoquinoline biosynthesis in fungi. Nat. Chem. Biol. 2016, 12, 419-424. [doi]
    Featured in C&E News, “Fungi make isoquinolines” [link]
    Featured in ScienceDaily [link]
    Featured in Faculty of 1000 [link]
  11. Hind, S.R.; Strickler, S.R.; Boycle, P.C.; Bao, Z.; O’Doherty, I.M.; Baccile, J.A.; Dunham, D.M.; Viox, E.G.; Clarke, C.R.; Vinatzer, B.A.; Schroeder, F.C.; Martin, G.B.; Tomato receptor FLAGELLIN-SENSING 3 perceived flagellin and confers disease resistance. Nat. Plants. 2016, 2, Article number 16128. [doi]
  12. Wever, W.J.; Bogart, J.W.; Baccile, J.A.; Chan, A.N.; Schroeder, F.C.; Bowers, A.A.; Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4+2] Cycloaddition. J. Am. Chem. Soc. 2015, 137, 3494-3497. [doi]
  13. Macheleidt, J.; Scherlach, K.; Neuwirth, T.; Schmidt-Heck, W.; Straßburger, M.; Spraker, J.; Baccile, J. A.; Schroeder, F. C.; Keller, N. P.; Hertweck, C.; Heinekamp, T. and Brakhage, A. A.; Transcriptome analysis of cyclic AMP-dependent protein kinase A–regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Molecular Microbiology, 2015, 96,148–162. [doi]
  14. Wiemann, P.; Lechner, B.E.; Baccile, J.A.; Velk, T.A.; Yin, W-B; Bok, J.W.; Pakala, S.; Losada, L.; Nierman, W.C.; Schroeder, F.C.; Haas, H.; Keller, N.P.; Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus. Front. Microbiol. 2014, 5, 530. [doi]
  15. *Yin, W.; *Baccile, J.A.; Bok, J.W.; Chen, Y.; Keller, N.P.; Schroeder, F.C.; A Nonribosomal Peptide Synthetase-Derived Iron(III) Complex from the Pathogenic Fungus Aspergillus fumigatus. J. Am. Chem. Soc. 2013, 135, 2064-2067. [doi]
  16. Baccile, J.A.; Morrell, M.A.; Falotico, R.M; Milliken, B.T.; Drew, D.L.; Rossi, F.M.; Modular synthesis of photocleavable peptides using click chemistry. Tetrahedron Lett. 2012, 53, 1933-1935. [doi]

(* indicates equal contribution)


Contact Information

  • 322 Dabney-Buehler Hall
  • 1416 Circle Drive
  • Knoxville, TN 37996-1600
  • Phone: 865-974-6130
  • E-mail: jbaccile@utk.edu