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Shawn Campagna

Shawn R. Campagna



Research in my group will use organic synthesis, combinatorial methods, and analytical techniques, such as tandem liquid chromatography-mass spectrometry and nuclear magnetic resonance, to answer biologically relevant questions at the molecular level. We have also established collaborations with a number of other researchers, both at UTK and at other universities, and these interactions have enhanced our ability to explore the underlying chemical component of a variety of biological processes. The figure below gives an overview of the research in our laboratory, and more detailed descriptions of the projects will be posted soon.

Campagna Research


Dr. Campagna completed his B.S. in Chemistry at North Carolina State University in 2000 and conducted research with Prof. Jonathan S. Lindsey on the chemical synthesis of bacterial chromosomes. He received his Ph.D. from Princeton University in 2006, after working with Prof. Martin F. Semmelhack on a joint project with Profs. Bonnie L. Bassler and Frederick M. Hughson to characterize the chemical properties of an inter-species bacterial signaling molecule, autoinducer-2. Dr. Campagna then performed post-doctoral fellow research with Prof. Joshua D. Rabinowitz at the Lewis-Sigler Institute for Integrative Genomics at Princeton University where he developed mass spectrometric methods for the identification of novel biochemical pathways and natural products from whole cell extracts. He joined the Chemistry Department at UT Knoxville in August 2007.


B.S., North Carolina State University (2000)
Ph.D., Princeton University (2006)

Awards and Recognitions

Atlantic Richfield Professor 2012-2015


Burke, S. J., May, A. L., Noland, R. C., Lu, D., Brissova, M., Powers, A. C., Sherrill, E. M., Karlstad, M. D., Campagna, S. R., Stephens, J. M., Collier, J. J., “Thiobenzothiazole-modified hydrocortisones display anti-inflammatory activity with reduced impact on islet β-cell function.” Journal of Biological Chemistry, 2015, 290(21), 13401-13416.

Im, J., Prevatte, C.W.,* Campagna, S. R., Löffler, F. E., “Identification of 4-hydroxycumyl alcohol as the major MnO2-mediated bisphenol A transformation product and evaluation of its environmental fate.” Environmental Science and Technology, 2015, 49(10), 6214-6221.

Dunham, B. P., Sharma, S., Luo, H., Smith, C. B., Amin, S. A., Bender, S. J., Dearth, S. P., * Van Mooy, B. A. S., Cmpagna, S. R., Kujawinski, E. B., Armbrust, E. V., Moran, M. A., “Cryptic carbon and sulfur cycling between surface ocean plankton.” PNAS USA, 2015, 112(2), 453-457.

Cheema, M., Mohan, M. S., Campagna, S. R., Jurat-Fuentes, J. L., Harte, F. M., “The association of low-molecular-weight hydrophobic compounds with native casein micelles in bovine milk.” Journal of Dairy Science, 2015, 98(8), 5155-5163.

Rymer, J. K., Hauser, M., Bourdon, A. K.,* Campagna, S. R., Naider, F., Becker, J. M., “Novobiocin and peptide analogs of a-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p.” Biochimica et Biophysica Acta – Biomembranes, 2015, 1848(4), 916-924.

Cude, W. N., Prevatte, C. W.,* Hadden, M. K., Smith, R. T.,** Swain, C. L.,** Campagna, S. R., Buchan, A. “Phaeobacter sp. strain Y4I utilized two separate cell-to-cell communication systems to regulate production of the antimicrobial indigoidine.” Applied and Environmental Microbiology, 2015, 81(4), 1417-1425.

Richardson, L. L., Stanic, D., May, A. L.,* Brownell, A., Gantar, M., Campagna, S. R., “Ecology and physiology of the pathogenic cyanobacterium Roseofilum reptotaenium.” Life, 2014, 4(4), 968-987.

Zimmer, B. L., May, A. L.,* Bhedi, C.D., Dearth, S. P.*, Prevatte, C. W.,* Pratte, Z., Campagna, S. R., Richardson, L. L., “Quorum sensing signal production and microbial interactions in a polymicrobial disease of corals and the coral surface mucopolysaccharide layer.” PLoS One, 2014, 9(9), e108541.

Steffen, M. M.,* Dearth, S. P.,* Dill, B. D., Li, Z., Campagna, S. R., Wilhelm, S. W., “Nutrients drive transcriptional changes that maintain metabolic homeostatsis but alter genome architecture in Microcystis.” ISME Journal, 2014, 8(10), 2080-2092.

Steill, J. D., May, A. L.,* Campagna, S. R., Oomens, J., Compton, R. N. “Structure and Stability of Phenoxide and Fluorophenoxide Anions Investigated with Infrared Multiple-Photon Dissociation and Detachment Spectroscopy and Tandem Mass Spectrometry.” Journal of Physical Chemistry A, 2014, 118(37), 8597-8605.

Artegoitia, V. M.,* Middleton, J. L.,* Harte, F. M., Campagna, S. R., de Veth, M. J., “Choline and Choline Metabolite Patterns and Associations in Blood and Milk during Lactation in Dairy Cows.” PLoS One, 2014, 9(8), e103412.

Im, J., Prevatte, C. W.,* Lee, H. G., Campagna, S. R., Löffler, F. E., “4-methylphenol produced in freshwater sediment microcosms is not a bisphenol A metabolite.” Chemosphere, 2014, 117(1), 521-526.

Ji, B,* Middleton, J. L.,* Ernest, B.,* Saxton, A. M., Lamont, S. J., Campagna, S. R., Voy, B. H. “Molecular and metabolic profiles suggest that increased lipid catabolism in adipose tissue contributes to leanness in domestic chickens.” Physiological Genomics, 2014, 46(9), 315-327.

Kolker, E., campagna, S. R., dearth, S. P.,* May, A. L.,* et al. “Toward More Transparent and Reproducible Omics Studies Through Common Metadata Checklist and Data Publications.” Omics: A Journal of Integrative Biology/Big Data, 2014, 18(1), 10-14.

Ankrah, N.,* May, A. L.,* Middleton, J. L.,* Jones, D.,** Hadden, M., Gooding, J. R.,* LeCleir, G., Wilhelm, S. W., Campagna, S. R. “Phage infection of an environmentally relevant marine bacterium alters host metabolism and lysate composition” ISEM J, 2013, 8(5), 1089-1100.

Kosentka, P.,* Sprague, S. L.,** Ryberg, M., Gartz, J., May, A. L.,* Campagna, S. R., Matheny, P. B. “Evolution of the Toxins Muscarine and Psilocybin in a Family of Mushroom-Forming Fungi.” PLoS One, 2013, 8(5), e64646.

Russell, M. H.,* Bible, A. N.,* Fang, X., Gooding, J. R.,* Campagna, S. R., Gomelsky, M., Alexandre, G., “Integration of the second messenger c-di-GMP into the chemotactic signaling pathway.” mBio, 2013, 4(2)

Ernest, J. B.,* Gooding, J. R.,* Campagna, S. R., Saxton, A. M., Voy, B. H., “MetabR: An R script for linear model analysis of quantitative metabolomic data.” BMC Research Notes, 2012, 5:596.

Ji, B.,* Ernest, B.,* Gooding, J. R.,* Das, S., Saxton, A. M., Dupont, J., Métayer-Coustard, S., Campagna, S. R., Voy, B. H., “Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting” BMC Genomics, 2012

Saenz, G. C., Underwood, A., Belapure, S. A.,* Campagna, S. R., Sun, Z., Tammariello, S., Rickard, A. H.  “Autoinducer-2 influences interactions amongst pioneer colonizing Streptococci in oral biofilms.” Microbiology, 2012, 158(7), 178301795.

Tonner, R., Schwerdtfeger, P., May, A. L.,* Steill, J. D., Bergen, G., Oomens, J., Campagna, S. R., Compton, R. N. “Stability of gas-phase tartaric acid anions investigated by quantum chemistry, mass spectrometry, and infrared spectroscopy.” Journal of Physical Chemistry A, 2012, 116(19), 4789-4800.

May, A. L.,* Eisenhauer, M. E.,* Coulston, K. S.,** Campagna, S. R. “Detection and quantitation of bacterial acylhomoserine lactone quorum sensing molecules via liquid chromatography–isotope dilution tandem mass spectrometry.” Analytical Chemistry, 2012, 84(3), 1243-1252.

Van Mooy, B. A. S., Hmelo, L. R., Mincer, T. J., Sofen, L. E., Campagna, S. R., May, A. L.,* Dyhrman, S. T., Webb, E. A., Momper, L. “Quorum sensing control of phosphorus acquisition in Trichodesmium colonies.” The ISME Journal, 2012, 48, 422-429.

Van Mooy, B. A. S.; Hmelo, L. R.; Mincer, T. J.; Sofen, L. E.; Campagna, S. R.; May, A. L.; Dyhrman, S. T.; Webb, E. A.; Momper, L.,  Quorum sensing control of phosphorus acquisition in Trichodesmium colonies. The ISME Journal, 8 September 2011; doi:10.1038/ismej.2011.115

Clasquin, M. F.; Melamud, E.; Singer, A.; Gooding, J. R.; Xu, X.; Dong, A.; Cui, H.; Campagna, S. R.; Savchenko, A.; Yakunin, A. F.; Rabinowitz, J. D.; Caudy, A. A., Riboneogensis in yeast. Cell, 2011, 145(6), 969-980.

Collier, J.J.; Burke, S. J.; Eisenhauer, M. E.; Lu, D.; Sapp, R. C.; Frydman, C. J.; Campagna, S. R., Pancreatic b-cell Death in Response to Pro-inflammatory Cytokines is Distinct from Genuine Apoptosis. PLoS One, 2011, 6(7), e22485.

Gooding, J. R.; May, A. L.; Hilliard, K. R.; Campagna, S. R., Establishing a Quantitative Definition of Quorum Sensing Provides Insight into the Information Content of the Autoinducer Signals in Vibrio harveyi and Escherichia coli. Biochemistry, 2010, 49(27), 5621-5623.

Fairchild J. N.; Horvath, K.; Gooding, J. R.; Campagna, S. R.; Guiochon, G., Two-dimensional liquid chromatography/mass spectrometry/mass spectrometry separation of water-soluble metabolites. J. Chromatography A,2010, 1217(52), 8161-6.

Campagna, S. R.; Gooding, J. R.; May, A. L., Direct Quantitation of the Quorum Sensing Signal, Autoinducer-2, in Clinically Relevant Samples by Liquid Chromatography-Tandem Mass Spectrometry. Analytical Chemistry 2009, 81 (15), 6374-6381.

Semmelhack, M. F.; Campagna, S. R.; Federle, M. J.; Bassler, B. L. "An expeditious synthesis of DPD and boron binding studies," Org. Lett., 2005, 7(4), 569-572.

Miller, S. T.; Xavier, K. B,; Campagna, S. R.; Taga, M. E.; Semmelhack, M. F.; Bassler, B. L.; Hughson, F. M. "Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal Al-2," Mol. Cell, 2004, 15(5), 677-687.

Shawn Campagna

Contact Information

  • 611 Buehler Hall
  • 1420 Circle Drive
  • Knoxville, TN 37996-1600
  • Phone: 865-974-7337
  • E-mail: