Post-Doc, University of Illinois at Urbana-Champaign

PhD, Chemistry from UC Santa Barbara

BS, Chemistry and Mathematics from Gonzaga University

My research combines ion-mobility mass spectrometry (IM-MS), mass spectrometry imaging (MSI), and computational modeling to bring a chemical physics outlook to problems of broad chemical interest. The overarching aims of my research are two-fold. The first is to develop fast and sensitive MS-based techniques and biophysical methods suitable for simultaneously assessing and predicting the structure, topology, composition and dynamics of exotic species in the gas phase. These species include small molecules, peptides and proteins in complex mixtures and volume-limited samples. The second overarching aim is to use these techniques for biological applications.

2022 ASMS Research Award

Limbach, M. N.¹; Antevksa, A.¹; Oluwatoba, D. S.; Gray, A. L. H.; Carroll, X. B.; Hoffmann, C. M.; Wang, X.; Voehler, M. W.; Steren, C. A.; Do, T. D. Atomic View of Aqueous Cyclosporine A: Unpacking a Decades-Old Mystery. J. Am. Chem. Soc. 2022, 144, 12602-12607. PDF. CCDC 2149649–2149650

Gray, A. L. H.; Sawaya, M. R.; Acharyya, D.; Jinchao, L.; Edington, E.; Best, M. D.; Prosser, R. A.; Eisenberg, D. S.; Do, T. D. Atomic View of an Amyloid Dodecamer Exhibiting Selective Cellular Toxic Vulnerability in Acute Brain Slices. Protein Science 2022, 31 (3), 716-727. PDF, PDB ID: 7ROJ, 7ROL

Sade Yazdi, D.; Bar-Yosef, D. L.; Adsi, H.; Kreiser, T.; Sigal, S.; Bera, S.; Zaguri, D.; Shaham-Niv, S.; Oluwatoba, D. S.; Levy, D.; Gartner, M.; Do, T. D.; Frenkel, D.; Gazit, E. Homocysteine fibrillar assemblies display cross-talk with Alzheimer’s disease β-amyloid polypeptide. Proc. Natl. Acad. Sci. U.S.A. 2021, 118 (24), e2017575118.

Gray, A. L. H.¹; Antevska, A.¹; Link, B. A.; Bogin, B.; Burke, S.; Dupuy, S.; Collier, J. J.; Levine, Z.; Karlstad, M.; Do, T. D. α-CGRP Disrupts Amylin Fibrillization and Regulates Insulin Secretion: Implications on Diabetes and Migraine. Chem. Sci. 2021, 12, 5853-5864.

Neumann, E. K.; Do, T. D. ; Comi, T. J.; Sweedler, J. V. Exploring the Fundamental Structures of Life: Non-targeted, Chemical Analysis of Single Cells and Subcellular Structures. Angew. Chem. Int. Ed. 2019, 31, 9448 – 9465.