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Thanh Do

Assistant Professor


My research combines ion-mobility mass spectrometry (IM-MS), mass spectrometry imaging (MSI), and computational modeling to bring a chemical physics outlook to problems of broad chemical interest. The overarching aims of my research are two-fold. The first is to develop fast and sensitive MS-based techniques and biophysical methods suitable for simultaneously assessing and predicting the structure, topology, composition and dynamics of exotic species in the gas phase. These species include small molecules, peptides and proteins in complex mixtures and volume-limited samples. The second overarching aim is to use these techniques for biological applications.


Post-Doc, University of Illinois at Urbana-Champaign 

PhD, Chemistry from UC Santa Barbara 

BS, Chemistry and Mathematics from Gonzaga University

Awards and Recognitions

2022 ASMS Research Award


Limbach, M. N.1Antevksa, A.1Oluwatoba, D. S.Gray, A. L. H.; Carroll, X. B.; Hoffmann, C. M.; Wang, X.; Voehler, M. W.; Steren, C. A.; Do, T. D. Atomic View of Aqueous Cyclosporine A: Unpacking a Decades-Old MysteryJ. Am. Chem. Soc. 2022, 144, 12602-12607. PDF. CCDC 2149649-2149650

Gray, A. L. H.; Sawaya, M. R.; Acharyya, D.; Jinchao, L.; Edington, E.; Best, M. D.; Prosser, R. A.; Eisenberg, D. S.; Do, T. D. Atomic View of an Amyloid Dodecamer Exhibiting Selective Cellular Toxic Vulnerability in Acute Brain SlicesProtein Science 2022, 31 (3), 716-727. PDF, PDB ID: 7ROJ7ROL

Sade Yazdi, D.; Bar-Yosef, D. L.; Adsi, H.; Kreiser, T.; Sigal, S.; Bera, S.; Zaguri, D.; Shaham-Niv, S.; Oluwatoba, D. S.; Levy, D.; Gartner, M.; Do, T. D.; Frenkel, D.; Gazit, E. Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease β-amyloid polypeptideProc. Natl. Acad. Sci. U.S.A. 2021, 118 (24), e2017575118.

Gray, A. L. H.1Antevska, A.1Link, B. A.; Bogin, B.; Burke, S.; Dupuy, S.; Collier, J. J.; Levine, Z.; Karlstad, M.; Do, T. D. α-CGRP Disrupts Amylin Fibrillization and Regulates Insulin Secretion: Implications on Diabetes and MigraineChem. Sci. 2021, 12, 5853-5864.

Neumann, E. K.; Do, T. D. ; Comi, T. J.; Sweedler, J. V. Exploring the Fundamental Structures of Life: Non-targeted, Chemical Analysis of Single Cells and Subcellular StructuresAngew. Chem. Int. Ed. 2019, 31, 9448 - 9465.

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