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Home » Archives for September 2024

September 2024

Archives for September 2024

Remembering George K. Schweitzer

September 25, 2024 by Jennifer Brown

Black and white headshot photo

It is with great sadness that the Department of Chemistry announces the passing of Professor George K. Schweitzer. The longest serving faculty member in the history of the University of Tennessee, Schweitzer will be remembered for his pioneering work in inorganic chemistry and radiochemistry, and by the thousands of students he mentored and taught.

Born in Poplar Bluff, Missouri, Schweitzer earned a BA in chemistry from Central College in 1945. He went on to graduate studies at the University of Illinois, where he was granted a PhD in 1948. Schweitzer moved to Tennessee to join the chemistry faculty in 1948 and in 2023 celebrated his 75th year of teaching at UT.

During World War II, Schweitzer investigated an element similar to uranium and his dissertation work has been described as an extension of the Manhattan Project. He said he came to UT because of its proximity to the Oak Ridge National Laboratory and its relevance to his research. Upon his arrival, Schweitzer was charged with establishing the PhD programs for Inorganic and Radiochemistry.

Schweitzer described his first day of teaching as “a hoot,” noting that, at 23 years old, he was convinced most of the students in his class were older than him. He enjoyed telling the story of that day, when he joined class and sat down to listen to the students discussing the new professor and what they expected him to be like. When the bell sounded for his class to begin, Schweitzer stood and introduced himself to his students, who all laughed.

At a time when the university was just beginning to develop its identity, Schweitzer was already exemplifying what it means to be a Volunteer. He served as radiation safety officer for the State of Tennessee during the Cold War. His work contributed heavily to the development of photoelectron scanning instruments, technology that made some modern medical scanning equipment possible. He was fond of the saying, “I have come to serve, not to be served.”

In 1960, Schweitzer was named the inaugural Macebearer, an award presented to a faculty member who has exhibited longstanding commitment to the university and the community. His love of investigation and the pursuit of knowledge led him to earn an MA in philosophy from Columbia University, followed by a PhD in philosophy from New York University. He was later awarded a ScD for his work in the history of science.

Schweitzer’s colleagues remember him fondly, often recalling his devotion to continued learning. Fellow professor and inorganic chemist Ben Xue met Schweitzer for the first time soon after joining the university in 1992.

“I was deeply impressed by his knowledge of the world, broad interests, and sharp mind,” said Xue. “George was a unique scientist and colleague, and I will miss him.”

During Professor Schweitzer’s time at the university, he served under 13 UT presidents and seven department heads. He saw the creation of the UT College of Veterinary Medicine, the UT College of Nursing, and the development of the UT System itself. He was with the department when it moved into the then newly built Buehler Hall, after spending years working with its namesake, Calvin Buehler. He published more than 150 academic papers and authored 17 books on chemistry and local and family history, including a history of the Department of Chemistry at UT. In 1970 he was named an Alumni Distinguished Professor.

A man in a suit pointing at equipment in a lab

Though he cited his research as his greatest pride point, Schweitzer’s teaching legacy cannot be ignored. Over the years he mentored more than 140 graduate students, ushering them toward PhD and MS degrees. He taught classes in the chemistry, philosophy, history, and nuclear engineering departments, and had the unique experience of teaching the grandchildren of students he had taught before.

“In my four years at the University of Tennessee, I have met with many of our alumni,” said Viktor Nemykin, current head of the Department of Chemistry. “Everyone remembered George and wanted to talk to him. His more than 75 years of service to the department and university are truly unmatched.”

When asked if he planned to retire, Schweitzer once responded that he had considered it at one time, but he had since recovered. He continued to teach into the current academic year and had planned to teach in the spring. With a career as expansive as Professor Schweitzer’s, it is impossible to recount every important contribution made to his discipline, the university, and beyond. At 99 years old, he experienced and contributed to the making of the world as it exists today, teaching and conducting research through most of it. The university and department are unlikely to see his legacy matched, and he will be sorely missed.

Gifts in honor of Dr. Schweitzer may be made here: giving.utk.edu/schweitzer

Share your memories of Dr. Schweitzer with us here.

Filed Under: News Tagged With: Schweitzer

Courtney Christopher headshot photo

Chemistry Researcher Studies Human Health at the Molecular Level

September 16, 2024 by Jennifer Brown

Courtney Christopher started college as a pre-med major but realized chemistry could hold answers to complex human health questions. Now as a postdoctoral research fellow in the Department of Chemistry, she’s uncovering novel links between a microbial derived metabolite, the gut microbiome, and conditions ranging from systemic inflammation to Alzheimer’s disease.

Most of her postdoctoral work at the University of Tennessee, Knoxville, has stemmed from her discovery of 2,3-dihydroxypropane-1-sulfonate (DHPS) in humans.  

“Prior to my work, DHPS did not have a known role in human metabolism,” she explained. Her principal investigator is UT Chemistry Professor Shawn R. Campagna, who helped discover the role of DHPS in marine microbial communities a decade ago. 

“My contributions have been identifying DHPS in humans, discovering that this metabolite does impact human physiology, and providing data and generating hypotheses that will lay the foundation for future studies to uncover how DHPS may be a key regulator of human health and inflammation,” Christopher said.

She’ll be discussing all of her DHPS discoveries and summarizing the findings on DHPS in human health at the University of Tennessee Health Science Center’s Neuroscience Institute seminar series this October in Memphis.

This past summer she delivered oral presentations at the American Society for Mass Spectrometry and the American Chemical Society conferences, and her collaborator presented at the American Society for Microbiology conference. 

Vaping to Alzheimer’s

In one study, published in the journal metabolites, Christopher discovered a connection between DHPS and metabolic dysregulation, comparing DHPS levels in the stool of vaping and smoking subjects compared to controls. 

“This work provided the first evidence that DHPS, a microbial metabolite with an unknown role in human physiology, may be linked to vaping and smoking-induced metabolic dyshomeostasis and a basis for future research investigating the role of DHPS in human health,” she said. “I also identified correlations to cholesterol metabolism, acetylated amino acids, neurotransmitters, and vitamin B metabolism, which may provide insight into the physiological role of DHPS.”

In another, she discovered a previously unrecognized link between DHPS and neurodegenerative diseases (NDDs) such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS). “The data suggest that cryptic sulfur metabolism via DHPS is a missing link in our current understanding of NDD onset and progression,” Christopher said.

Her hypothesis is that metabolic dyshomeostasis and increased flux through DHPS result in mitochondrial dysfunction and systemic inflammation in humans.

This academic year she is investigating the pathophysiological impact of DHPS dyshomeostasis on mitochondrial dysfunction. “Additionally, I plan to study how different intrinsic (biological sex, aging) and extrinsic factors (diet, diabetes, hypertension) are impacted by DHPS dyshomeostasis,” she said. 

Interdisciplinary Collaborations

Christopher was working on her bachelor’s degree in chemistry at Lincoln Memorial University when she first heard of the work in the Campagna Lab at UT using mass spectrometry-based metabolomics to investigate the etiology of Alzheimer’s disease. 

“I was so impressed with Dr. Campagna’s research on human health and his many interdisciplinary research collaborations with PIs (principal investigators) across the country.” She earned her PhD from UT in 2022.

“None of this work would have been possible without my mentor (Campagna) and incredible collaborators,” Christopher said, “Through the Biological and Small Molecule Mass Spectrometry Core (BSMMSC) in UT’s Department of Chemistry, I have had the opportunity to collaborate with brilliant scientists across the globe. They have given me scientific freedom to explore this new discovery and have provided invaluable support.”

Her collaborators include Assistant Professor Katie Morgan from the UT College of Nursing, as well as researchers from Augusta University, the Medical University of South Carolina, and Louisiana State University.

By Amy Beth Miller

Filed Under: Analytical Chemistry, News

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