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Home » Jenkins Lab Published in Angewandte Chemie

Jenkins Lab Published in Angewandte Chemie

Jenkins Lab Published in Angewandte Chemie

March 1, 2023 by Jennifer Brown

The Jenkins Lab published their research “Giving Gold Wings: Ultrabright and Fragmentation Free Mass Spectrometry Reporters for Barcoding, Bioconjugation Monitoring, and Data Storage” in the international journal Angewandte Chemie. Graduate students Isabel Jensen and Gurkiran Kaur were co-authors on the piece. 

The widespread application of laser desorption/ionization mass spectrometry (LDI-MS) highlights the need for a bright and multiplexable labeling platform. While ligand-capped Au nanoparticles (AuNPs) have emerged as a promising LDI-MS contrast agent, the predominant thiol ligands suffer from low ion yields and extensive fragmentation.

In this work, they developed a N-heterocyclic carbene (NHC) ligand platform that enhances AuNP LDI-MS performance. NHC scaffolds are tuned to generate barcoded AuNPs which, when benchmarked against thiol-AuNPs, are bright mass tags and form unfragmented ions in high yield. To illustrate the transformative potential of NHC ligands, the mass tags were employed in three orthogonal applications: monitoring a bioconjugation reaction, performing multiplexed imaging, and storing and reading encoded information.

These results demonstrate that NHC-nanoparticle systems are an ideal platform for LDI-MS and greatly broaden the scope of nanoparticle contrast agents.

Filed Under: Inorganic Chemistry, News Tagged With: inorganic, Jenkins

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